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Tuesday, 30 April 2013

Organic Chemistry Portal Reactions >> Name Reactions Further Information Literature Related Reactions Buchwald-Hartwig Coupling Chan-Lam Coupling Ullmann Reaction Williamson Synthesis

Williamson Synthesis


This method is suitable for the preparation of a wide variety of unsymmetric ethers. The nucleophilic substitution of halides with alkoxides leads to the desired products.
If the halides are sterically demanding and there are accessible protons in the β-position, the alkoxide will act as a base, and side products derived from elimination are isolated instead.

Mechanism of the Williamson Synthesis

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