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Tuesday, 30 April 2013

Favorskii Reaction

Favorskii Reaction


The rearrangement of cyclopropanones, often obtained as intermediates from the base-catalyzed reaction of α-halo ketones, leading to carboxylic acids and derivatives.

Mechanism of the Favorskii Reaction


Esters are obtained if alkoxide bases are used:

A direct conversion from α-halo ketones is possible:

Ring-contraction:

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