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Sunday, 14 July 2013

Fischer esterification mechanism

Fischer esterification mechanism
Overview:
The general form of Fischer esterification mechanism is as follows:



The first step involves protonation of the carbonyl oxygen, followed by the nucleophillic attack of the alcohol.

Then a loss and regain of a proton,

followed by loss of water as electrons from the alcohol oxygen kick down to form the double bond. Loss of a proton yields the ester.
Example of fischer esterification:


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