Overview: The general form of the nucleophilic addition to carbonyl group mechanism is as follows: First step is the attack of the nucleophile on the partially positive carbon to make the tetrahedral intermediate with the full negatively charged oxygen. The oxygen then becomes protonated to yield the alcohol. Variety of nucleophiles:
In this case, acetylide anion is acting as the nucleophile |
Sunday, 14 July 2013
Nucleophilic addition to carbonyl groups
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