Barton-McCombie Reaction

Mechanism of the Barton-McCombie Reaction

Barton Vinyl Iodide Synthesis

Mechanism of the Barton Vinyl Iodide Synthesis

Barton Decarboxylation

Mechanism of the Barton Decarboxylation

Baker-Venkataraman Rearrangement

Mechanism of the Baker-Venkataraman Rearrangement

Baeyer-Villiger Oxidation

Mechanism of the Baeyer-Villiger Oxidation

Appel Reaction

Mechanism of the Appel Reaction

Alkyne Zipper Reaction

Mechanism of the Alkyne Zipper Reaction

Aldol Addition

Mechanism of the Aldol Addition

Aldol Condensation

Mechanism of the Aldol Condensation

Barbier reaction

Primary References

• Barbier, P. Compt. Rend., 1899, 128, 110.
• The original Barbier reaction combined a ketone, magnesium metal, and an alkyl halide in situ to give a substituted alcohol product.
  

• Recent Examples

  • Zhou, J-Y.; Jia, Y.; Sun, G-F.; Wu, S-H.* Synth. Commun., 1997, 27, 1899-1906.
  
  

           This is a Barbier-type coupling.

Baeyer-Villiger Oxidation

• Primary Reference

  • Baeyer, A.; Villiger, V. Ber., 1899, 24, 3625.
  • Baeyer, A.; Villiger, V. Ber., 1900, 33, 858.
  • House, H.O. Modern Synthetic Reactions, 2nd Ed. 1972,, Benjamin; Menlo Park, CA., pp. 306-307, 321-328.
  
  

• Recent Examples

  • Wiberg, K.B.;* Snoonian, J.R. J. Org. Chem., 1998, 63, 1390-1401.
  
  
  • Burton, J.W.; Clark, J.S.; Derrer, S.; Stork, T.C.; Bendall, J.G.; Holmes, A.B. J. Am. Chem. Soc., 1997, 119, 7483-7498.
  
  
  • Mino, T.; Masuda, S.; Masayuki, N.; Yamashita, M.* J. Org. Chem., 1997, 62, 2633-2635.